Product Description Model NO.: CAS No 319460-85-0 Molecular Formula: C22h18n4OS CAS: 319460-85-0 Specification: GMP, ISO HS Code: 3001200010 Name: Axitinib Molecular Weight: 386.47 Trademark: gongchuang Origin: Hubei
Product Description
Chemical Information

Product Name	Axitinib
Molecular Formula	C22H18N4OS
Molecular Weight	386.47
Storage	Store at -20°C
Targets	VEGFR-1        VEGFR-2         VEGFR-3
IC50	1.2 nM                0.2 nM          0.1 to 0.3 nM

Description
Axitinib is a selective and oral inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases 1, 2 and 3 with .
Axitinib inhibited the phosphorylation of VEGFR-1, 2 and 3 with IC50 values of 1.2 nM, 0.2 nM and 0.1 to 0.3 nM in cells, respectively. In HUVEC cells, Axitinib inhibited VEGFR-2 stimulated cell survival with about 1000-fold selectivity against FGFR-1. Axitinib also significantly suppressed the phosphorylation of VEGF downstream signaling molecules including Akt, eNOS and ERK1/2. Besides that, axitinib inhibited VEGFR-2 phosphorylation with EC50 value of 0.49 nM in vivo. It delayed tumore growth of human xenograft tumors in mice such as M24met, HCT-116 and SN12C .
 
General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.


Other Small molecular API:

AZD9291	1421373-65-0
E7080	417716-92-8
Afatinib diMaleate	439081-18-2
XL184 S-MALATE	1140909-48-3
Crizotinib	877399-52-5
Axitinib	319460-85-0
WZ4002	1213269-23-8
Vandetanib	443913-73-3
Sunitinib	557795-19-4
Regorafenib	755037-03-7
Imatinib	152459-95-5

 

 
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