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Home > Products > Pharmaceutical Intermediate > 99% Purity Sarms Powder Gw-0742/Gw610742 CAS: 317318-84-6
99% Purity Sarms Powder Gw-0742/Gw610742 CAS: 317318-84-6
  • 99% Purity Sarms Powder Gw-0742/Gw610742 CAS: 317318-84-6
Payment Type: T/T, Western Union, Money Gram, Bitcoin
Min. Order: 10
Basic Info

Model No.:  317318-84-6

Product Description Model NO.: 317318-84-6 Customized: Customized Suitable for: Adult Purity: >99% Packing: Well Disguised Package or as Your Requirement Delivery: 3-6 Days to Your Detailed Address Trademark: YCSC Origin: Wuhan, China Powder: Yes Certification: GMP, USP, BP State: Solid Appearance: White Powder Shipment: EMS, Hkems, FedEx, DHL, TNT, UPS Policy: Reship and Discount Specification: 99% assay 99% Purity Sarms Powder GW-0742/GW 610742  CAS: 317318-84-6
Name: GW-0742
Other Name: GW610742
CAS: 317318-84-6
Molecular Formula:C21H17F4NO3S2
Formula Weight:471.5
GW-0742 Form:solid
GW-0742 Color:white
GW-0742 Mp:134.5-135.5 °C
GW-0742 Solubility  DMSO: >5 mg/mL
                H2O: insoluble
GW-0742 Storage temp. 2-8°C

GW-0742 Description:
GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.
A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator 2. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner. The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.

Sarms List:
AICAR 2627-69-2
Andarine (GTX-007)(S4) 401900-40-0
GW-501516/Cardarine 317318-70-0
LGD-4033 1165910-22-4
MK-677 (Ibutamoren) 15972-10-0
MK-2866 (Ostarine) 841205-47-8
RAD-140 1182367-47-0
SR9009 1379686-30-2
SR9011 1379686-29-9
YK11 366508-78-3,431579-34-9 

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than 16 years experience in disguising packages
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