Product Description Model NO.: CAS 128270-60-0 Customized: Customized Suitable for: Adult Purity: >99% Sequence: D-Phe-PRO-Arg-PRO-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe- CAS No: 128270-60-0 Molecular Weight: 2180.29 Grade: Pharmaceutical Grade Specification: USD standard HS Code: 3001200010 Powder: Yes Certification: HSE, ISO 9001, USP State: Solid Product Name: Bivalirudin Trifluoroacetate Alias: Angiomax;Bivalirudin;Hirulog Molecular Formula: C98h138n24o33 Appearance: White Powder Trademark: yuancheng Origin: Hubei, China                                                          CAS 128270-60-0 Bivalirudin
 

Product Name	Bivalirudin Trifluoroacetate
Alias	Angiomax;Bivalirudin;Hirulog
Cas No	128270-60-0
Molecular Formula	C98H138N24O33
Molecular Weight	2180.29
Appearance	White Powder
Grade	Pharmaceutical Grade
Single Impurity	1.0%max

Description:
 
Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).
Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. Bivalirudin has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS). It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.
Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials
 
Application:
 
Bivalirudin is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA).
Bivalirudin with provisional use of glycoprotein IIb/IIIa inhibitor (GPI) is indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI).
Bivalirudin is indicated for patients with, or at risk of HIT/HITTS undergoing PCI.
Bivalirudin is intended for use with aspirin and has been studied only in patients receiving concomitant aspirin.


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