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Model No.: 73-78-9
Product Name: | Lidocaine HCL |
Synonyms: | |
CAS: | 73-78-9 |
MF: | C14H23ClN2O |
MW: | 270.8 |
EINECS: | 200-803-8 |
Product Categories: | API;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Research Chemical;Pharma materials |
Mol File: | 73-78-9.mol |
1)Details: Hemodynamics: Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. With central neural blockade these changes may be attributable to block of autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system and/or the beta-adrenergic receptor stimulating action of epinephrine when present. The net effect is normally a modest hypotension when the recommended dosages are not exceeded. 2)Application: Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine. Approximately 90% of Lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2, 6-dimethylaniline. |
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Product Categories : Pharmaceutical Intermediate